Lino-C Injection
Lino-C Injection
(Clindamycin 300 mg/2 ml)
Class: Lincosamide Parenteral Antibiotic
Lino-C Injection contains Clindamycin, a lincosamide antibiotic effective against Gram-positive aerobes and a wide range of anaerobic bacteria. It is used for serious infections requiring injectable therapy.
Antibacterial Spectrum:
- Gram-positive aerobes (e.g., Staphylococcus, Streptococcus)
- Anaerobic bacteria (both Gram-positive and Gram-negative)
Mechanism of Action:
- Clindamycin binds to the 50S subunit of bacterial ribosomes, inhibiting early stages of protein synthesis.
- Bacteriostatic at therapeutic levels
- Slowly bactericidal at higher concentrations against susceptible strains
Indications:
- Septicemia
- Intra-abdominal infections
- Lower respiratory tract infections
- Gynecological infections
- Bone and joint infections
- Skin and soft tissue infections
- Streptococcal pharyngitis
- Acne vulgaris
- Bacterial vaginosis
- Severe pelvic inflammatory disease (PID)
Precautions:
Use with caution in patients with a history of gastrointestinal disease, particularly colitis
Drug-Drug Interactions:
- Avoid use with skeletal muscle relaxants
- Increased risk of bleeding when used with vitamin K antagonists (e.g., warfarin, acenocoumarol) due to altered PT/INR levels
Contraindications:
- Known hypersensitivity to clindamycin or any component
- Pregnancy and lactation unless clearly needed
Warnings:
- May disrupt normal intestinal flora, leading to Clostridioides difficile-associated diarrhea (CDAD)
- Monitor for signs of pseudomembranous colitis
Side Effects:
- Pseudomembranous colitis
- Nausea, vomiting, diarrhea
- Hypersensitivity reactions (rare)
Dosage and Administration:
- Serious infections: 600 mg to 1.2 g/day in 2–4 divided doses
- Severe infections: 1.2 g to 2.7 g/day in 2–4 divided doses
- Important Administration Guidelines:
- Do not give single IM injections >600 mg
- Do not exceed 1.2 g in a single 1-hour IV infusion
- IV infusion concentration should not exceed 18 mg/ml
- Infusion rate must not exceed 30 mg/min
| Ingredient | Strength |
|---|---|
| Clindamycin | 300 mg / 2 ml (Each ml contains 150 mg) |
