Arclav 625 Tablet
Arclav 625 Tablet
[Each film-coated tablet contains: Amoxycillin 500 mg + Potassium Clavulanate 125 mg]
Arclav-625 provides beta-lactamase protected amoxicillin in combination with clavulanate.
Antibacterial Spectrum:
This drug combination offers broader coverage by combining:
- Amoxicillin – a penicillin derivative effective against Gram-positive and Gram-negative bacteria
- Clavulanic acid – counters β-lactamase–producing strains
Effective against methicillin-sensitive Staphylococcus aureus (MSSA) and Neisseria species.
Mechanism of Action:
- Peptidoglycan synthesis involves DD-transpeptidases (penicillin-binding proteins – PBPs).
- Amoxicillin binds with PBPs and inhibits peptidoglycan synthesis.
- This disrupts bacterial cell wall formation, leading to bactericidal lysis.
Indications:
- Community-acquired pneumonia (CAP)
- Acute bacterial rhinosinusitis
- Chronic group A streptococci carriers
- Small intestinal bacterial overgrowth (SIBO)
- Aspiration pneumonia
- Urinary tract infection
- Acute otitis media
- Skin or soft tissue infections
- Bite wounds
- Diabetic foot infections
- Odontogenic infections
Drug-Drug Interaction:
- Avoid skeletal muscle relaxants
- Co-administration with vitamin K antagonists (e.g., warfarin, acenocoumarol, fluindione) may increase coagulation tests (PT/INR) and risk of bleeding
Pharmacokinetics:
- Route of Administration: Oral
- Distribution: Widely distributed in body tissues/fluids (except brain/spinal fluid); detected in middle ear effusions
- Metabolism: Both components are metabolized into inactive compounds
- Excretion: Primarily eliminated via urine
Contraindications:
Hypersensitivity to any ingredient of the preparation
Precautions:
Watch for secondary infections like C. difficile colitis or candidiasis
Warnings:
May cause severe hepatitis and renal failure
Side Effects:
Diarrhea, Nausea, Vomiting, Abdominal discomfort
Dosage and Administration:
500 mg every 8 to 12 hours, or as directed by the Physician (Healthcare provider)
| Ingredient | Amount |
|---|---|
| Amoxycillin Trihydrate | 500mg (eq. to Amoxycillin) |
| Potassium Clavulanate | 125mg (eq. to Clavulanic Acid) |
