Rexio-AP
Rexio-AP
Each Film coated tablet contains : Aceclofenac 100 mg + Paracetamol 325 mg + Serratiopeptidase 15 mg ((as enteric coated)
Rexio-AP is a triple-action formulation designed to address inflammation, pain, and swelling. It is especially effective in musculoskeletal conditions due to its synergistic combination of anti-inflammatory, analgesic, and proteolytic enzyme components.
Mechanism of Action:
- Aceclofenac inhibits the cyclooxygenase (COX) enzyme, thereby blocking the synthesis of prostaglandins, mediators of inflammation and pain.
- Serratiopeptidase, a proteolytic enzyme, breaks down inflammatory exudates and fibrin deposits, facilitating tissue repair and faster healing.
- Paracetamol acts centrally on the pain pathway, reducing pain perception without causing significant gastric irritation.
Indications:
- Osteoarthritis
- Rheumatoid arthritis
- Ankylosing spondylitis
- Back pain and neck pain
- Sciatica
- Sports injuries
- Post-surgical pain and inflammation
- Post-traumatic/accidental pain and inflammation
- Post-procedural inflammation
Precautions:
- May cause gastric discomfort, nausea, or vomiting
- Should be used cautiously in patients with hepatic or renal insufficiency
Warnings:
- Gastrointestinal risk: Prolonged use may increase the risk of ulcers, bleeding, or perforation
- Hepatic risk: Use with caution in individuals with pre-existing liver conditions
- Renal risk: Monitor kidney function in long-term use
Pharmacokinetics:
- Route of Administration: Oral
- Distribution: Widely distributed, including synovial fluid (Aceclofenac)
- Metabolism: Primarily hepatic
- Excretion: Mainly through urine
Contraindications:
- Hypersensitivity to any component
- Pregnancy and lactation
- Active gastric ulcer or gastrointestinal bleeding
Side Effects:
- Gastric hyperacidity
- Acid dyspepsia
- Flatulence
- Nausea and vomiting
Dosage and Administration:
- 1 tablet twice daily after food
- Or as directed by the physician or healthcare provider
| Ingredient | Strength |
|---|---|
| Aceclofenac IP | 100 mg |
| Paracetamol IP | 325 mg |
| Serratiopeptidase (as enteric coated) IP | 15 mg |
